SPATA7

Across TCGA cell cohorts, SPATA7 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPATA7-associated genes across cancer lineages are CCL11, OR9A2, and MAGEB3. Each is linked with SPATA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA7-to-partner and partner-to-SPATA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL11 grouped by SPATA7-low versus SPATA7-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA7→partner) and Y-score (partner→SPATA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CCL11 →	+0.015	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	OR9A2 →	+0.023	+4.510	<.001	.003	3	2
BLOOD_Leukemia	MAGEB3 →	+0.022	+5.269	<.001	<.001	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
OESOPHAGUS	TDRD15 →	+0.006	+4.906	<.001	.006	3	1
CNS	CEACAM3 →	+0.061	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

CCL11 by SPATA7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →