SPATA6L

Across TCGA patient cohorts, SPATA6L mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA6L-associated genes across cancer lineages are ACC1, Di-Ras3, and EGFR_pY1068. Each is linked with SPATA6L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA6L-to-partner and partner-to-SPATA6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by SPATA6L-low versus SPATA6L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA6L→partner) and Y-score (partner→SPATA6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.312	+1.807	.037	.027	3	2
UCEC	Di-Ras3 →	-0.153	-2.321	.012	.006	3	2
UCEC	EGFR_pY1068 →	-0.317	-2.700	.002	.006	3	1
UCEC	EGFR →	-0.203	-3.321	.002	.010	3	1
UCEC	A-Raf_pS299 →	-0.187	-3.700	<.001	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.105	.013	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ACC1 by SPATA6L expression — UCEC

Explore this box plot interactively →