SPATA48

Across TCGA pan-cancer cohorts, SPATA48 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPATA48 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SPATA48 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPATA48 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and COAD are the cancer types where SPATA48 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.631	.013	10	view →
COAD	OS	Median	II,III,IV	0.111	0.851	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPATA48–THYM (OS)

Open the THYM breakdown →