SPATA46

Across TCGA patient cohorts, SPATA46 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA46-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and c-Kit. Each is linked with SPATA46 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA46-to-partner and partner-to-SPATA46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SPATA46-low versus SPATA46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA46→partner) and Y-score (partner→SPATA46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.567	-3.159	<.001	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.730	+2.827	.025	.035	3	1
UCEC	c-Kit →	-0.252	-3.169	.049	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

STAT3_pY705 by SPATA46 expression — UCEC

Explore this box plot interactively →