SPATA46

Across TCGA pan-cancer cohorts, SPATA46 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPATA46 data layer compared with 5 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SPATA46 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPATA46 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and COAD are the cancer types where SPATA46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.959	0.846	<.001	58	view →
HNSC	OS	Median	IV	0.822	0.639	.001	57	view →
COAD	DFS	Median	All	0.706	0.849	<.001	38	view →
LIHC	OS	Tertile	III,IV	0.639	0.239	<.001	31	view →
SKCM	OS	Median	III,IV	0.708	0.914	.001	28	view →
MESO	DFS	Quartile	IV	0.155	0.623	.006	27	view →
KIRC	OS	Median	All	0.899	0.849	.004	25	view →
ACC	OS	Tertile	IV	0.901	0.449	.004	24	view →
THCA	DFS	Median	II,III,IV	0.615	0.838	.007	20	view →
CESC	DFS	Tertile	All	0.777	0.864	.007	16	view →
READ	DFS	Quartile	III,IV	0.328	0.669	.013	15	view →
KIRP	DFS	Median	IV	0.040	0.593	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPATA46–BRCA (OS)

Open the BRCA breakdown →