SPATA46

Across TCGA cell cohorts, SPATA46 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,364 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SPATA46-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Negative regulation of myoblast fusion, and Negative regulation of RNA splicing. Each is linked with SPATA46 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPATA46-to-partner and partner-to-SPATA46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by SPATA46-low versus SPATA46-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA46→partner) and Y-score (partner→SPATA46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.098	+0.212	.001	.004	3	9
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.116	+2.117	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.100	+0.300	.002	.009	3	8
BONE	Negative regulation of chromosome condensation →	+0.157	+0.409	<.001	<.001	3	8
OVARY	mRNA transcription →	+0.056	+0.178	<.001	.003	3	8
KIDNEY	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.190	+0.143	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,364 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by SPATA46 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →