Across TCGA cell cohorts, SPATA32 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATA32-associated genes across cancer lineages are PRSS58, OR4C12, and CLEC4G. Each is linked with SPATA32 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA32-to-partner and partner-to-SPATA32 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA32→partner) and Y-score (partner→SPATA32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1
SKIN	CLEC4G →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR2Z1 →	+0.020	+6.022	<.001	.001	3	1
BLOOD_Leukemia	RIMS4 →	+0.213	+3.675	.002	.003	3	1
BLOOD_Leukemia	MYL10 →	+0.015	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SPATA32 survival (RNA) · tumor vs normal (RNA) · all SPATA32 data types