SPATA31E1

Across TCGA patient cohorts, SPATA31E1 mutation is significantly associated with the RNA expression of many other genes, with 4,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31E1-associated genes across cancer lineages are CHEK2, METTL2A, and KXD1. Each is linked with SPATA31E1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATA31E1-to-partner and partner-to-SPATA31E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2 grouped by SPATA31E1-low versus SPATA31E1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31E1→partner) and Y-score (partner→SPATA31E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CHEK2 →	+0.325	+1.497	.004	.006	3	4
UCEC	METTL2A →	+0.339	+1.513	<.001	<.001	3	4
UCEC	KXD1 →	+0.236	+1.828	.004	.002	3	4
UCEC	VPS29 →	+0.342	+1.712	<.001	<.001	3	4
UCEC	CKS2 →	+0.594	+2.643	<.001	<.001	3	4
SKCM	METTL5 →	+0.333	+1.846	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,766 associations by consensus.

CHEK2 by SPATA31E1 expression — SKCM

Explore this box plot interactively →