SPATA31E1

Across TCGA patient cohorts, SPATA31E1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31E1-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and 53BP1. Each is linked with SPATA31E1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA31E1-to-partner and partner-to-SPATA31E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SPATA31E1-low versus SPATA31E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31E1→partner) and Y-score (partner→SPATA31E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.124	+1.064	.002	.043	3	3
COAD	Caspase-7-cleavedD198 →	+1.196	+2.008	<.001	.018	3	3
SKCM	53BP1 →	+0.235	+1.602	.043	.038	3	3
UCEC	Rad50 →	-0.165	-1.054	.017	.029	3	2
UCEC	FoxM1 →	+0.191	+1.222	.009	.011	3	2
UCEC	MEK1 →	+0.349	+2.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

C-Raf by SPATA31E1 expression — UCEC

Explore this box plot interactively →