SPATA31E1

Across TCGA cell cohorts, SPATA31E1 mutation is significantly associated with the RNA expression of many other genes, with 1,040 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA31E1-associated genes across cancer lineages are H2AB1, TAS1R2, and DEFB108B. Each is linked with SPATA31E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA31E1-to-partner and partner-to-SPATA31E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AB1 grouped by SPATA31E1-low versus SPATA31E1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31E1→partner) and Y-score (partner→SPATA31E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	H2AB1 →	+0.761	+3.523	.009	.009	3	2
LUNG_NSCLC_LUAD	TAS1R2 →	+0.006	+3.189	<.001	.007	3	2
LUNG_SCLC	DEFB108B →	+0.159	+3.232	<.001	.008	3	2
LARGE_INTESTINE	MAGEB4 →	+0.006	+2.415	.004	.009	3	2
OESOPHAGUS	IQCF1 →	+0.064	+3.906	.001	.007	2	2
OESOPHAGUS	GSG1L2 →	+0.026	+3.392	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,040 associations by consensus.

H2AB1 by SPATA31E1 expression — OESOPHAGUS

Explore this box plot interactively →