SPATA31D5P

Across TCGA patient cohorts, SPATA31D5P mutation is significantly associated with the RNA expression of many other genes, with 6,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31D5P-associated genes across cancer lineages are SMC2, SCNN1B, and OXSM. Each is linked with SPATA31D5P in more than 4 cancer types. Because this analysis shows association rather than direction, both SPATA31D5P-to-partner and partner-to-SPATA31D5P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMC2 grouped by SPATA31D5P-low versus SPATA31D5P-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31D5P→partner) and Y-score (partner→SPATA31D5P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC2 →	+0.683	+2.333	<.001	.003	3	5
LUSC	SCNN1B →	-1.082	-2.321	<.001	.005	3	4
COAD	OXSM →	+0.349	+3.183	.008	.009	3	4
LUAD	SKA1 →	+0.749	+3.035	.004	<.001	3	4
UCEC	EME1 →	+0.573	+2.055	<.001	<.001	3	4
SKCM	SUPV3L1 →	+0.415	+2.098	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,226 associations by consensus.

SMC2 by SPATA31D5P expression — LUAD

Explore this box plot interactively →