SPATA31D5P

Across TCGA patient cohorts, SPATA31D5P mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31D5P-associated genes across cancer lineages are Ku80, STAT3_pY705, and Src_pY527. Each is linked with SPATA31D5P in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATA31D5P-to-partner and partner-to-SPATA31D5P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SPATA31D5P-low versus SPATA31D5P-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31D5P→partner) and Y-score (partner→SPATA31D5P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Ku80 →	+0.321	+2.812	.014	.037	2	4
UCEC	STAT3_pY705 →	-0.294	-1.514	<.001	.012	3	3
UCEC	Src_pY527 →	-0.295	-1.668	.025	.021	3	3
BRCA	14-3-3_beta →	-0.183	-2.989	.023	.037	2	3
LUAD	PTEN →	-0.219	-2.222	.024	.010	3	2
LUAD	B-Raf →	+0.384	+1.874	.008	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Ku80 by SPATA31D5P expression — BRCA

Explore this box plot interactively →