SPATA3-AS1

Across TCGA pan-cancer cohorts, SPATA3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SPATA3-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPATA3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPATA3-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

KIRP, UVM, and UCEC are the cancer types where SPATA3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.203	0.611	<.001	75	view →
UVM	DFS	Median	All	0.635	0.828	.022	41	view →
UCEC	DFS	Tertile	All	0.791	0.887	.007	28	view →
CHOL	DFS	Quartile	All	0.200	0.786	.006	24	view →
LIHC	DFS	Quartile	All	0.347	0.479	.003	24	view →
ACC	OS	Quartile	II,III,IV	0.535	0.811	.002	23	view →
LGG	OS	Tertile	All	0.721	0.861	<.001	22	view →
HNSC	OS	Tertile	II,III,IV	0.808	0.703	.017	15	view →
MESO	OS	Median	IV	0.277	0.701	.008	12	view →
ESCA	OS	Median	All	0.659	1.000	.020	12	view →
KIRC	OS	Quartile	All	0.756	0.847	.009	11	view →
THYM	DFS	Median	III,IV	0.514	0.894	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SPATA3-AS1–KIRP (DFS)

Open the KIRP breakdown →