SPATA25

Across TCGA cell cohorts, SPATA25 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPATA25-associated genes across cancer lineages are AMELX and DEFB125. Each is linked with SPATA25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA25-to-partner and partner-to-SPATA25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMELX grouped by SPATA25-low versus SPATA25-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA25→partner) and Y-score (partner→SPATA25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AMELX →	+0.038	+4.977	<.001	.007	3	1
SKIN	DEFB125 →	+0.035	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

AMELX by SPATA25 expression — SKIN

Explore this box plot interactively →