SPATA25

Across TCGA cell cohorts, SPATA25 mutation is significantly associated with the mutation status of many other genes, with 101 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATA25-associated genes across cancer lineages are DNAAF2, ITPK1, and SRPX2. Each is linked with SPATA25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA25-to-partner and partner-to-SPATA25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF2 grouped by SPATA25-low versus SPATA25-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA25→partner) and Y-score (partner→SPATA25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAAF2 →	+4.321	+5.285	.005	.005	1	2
SKIN	ITPK1 →	+4.824	+5.392	.004	.004	1	1
SKIN	SRPX2 →	+4.824	+5.392	.004	.004	1	1
SKIN	NECTIN1 →	+4.239	+5.053	.007	.007	1	1
SKIN	MSH3 →	+5.824	+5.824	.002	.002	1	1
SKIN	NEK11 →	+4.239	+5.053	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

DNAAF2 by SPATA25 expression — BLOOD_Leukemia

Explore this box plot interactively →