SPATA24

Across TCGA patient cohorts, SPATA24 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA24-associated genes across cancer lineages are FTH1P14, NPM1P10, and TOMM22P3. Each is linked with SPATA24 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA24-to-partner and partner-to-SPATA24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTH1P14 grouped by SPATA24-low versus SPATA24-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA24→partner) and Y-score (partner→SPATA24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FTH1P14 →	+0.122	+5.790	.005	.003	3	1
COAD	NPM1P10 →	+0.139	+5.435	<.001	.005	3	1
COAD	TOMM22P3 →	+0.451	+5.435	<.001	.005	3	1
COAD	MTND2P20 →	+0.122	+5.080	.006	.008	3	1
COAD	RPS24P1 →	+0.297	+5.080	<.001	.008	3	1
COAD	RN7SL104P →	+0.227	+6.721	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

FTH1P14 by SPATA24 expression — COAD

Explore this box plot interactively →