SPATA24

Across TCGA pan-cancer cohorts, SPATA24 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPATA24’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPATA24 RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA24 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, LIHC, and COAD are the cancer types where SPATA24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.001	<.001	11	view →
LIHC	Male	II,III,IV	+1.170	<.001	9	view →
COAD	Female	All	−0.745	<.001	8	view →
KIRP	Male	III,IV	−0.869	<.001	7	view →
HNSC	Male	II,III,IV	+0.341	.006	6	view →
THCA	Male	All	−0.602	<.001	5	view →
LUAD	All	All	+0.361	<.001	4	view →
BRCA	All	All	+0.257	.019	4	view →
CHOL	All	All	+1.325	<.001	3	view →
ESCA	All	II,III,IV	+0.999	.003	2	view →
LUSC	All	All	+0.374	<.001	2	view →
PRAD	All	All	+0.370	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPATA24–KICH

Open the KICH breakdown →