SPATA24

Across TCGA patient cohorts, SPATA24 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA24-associated genes across cancer lineages are naive B-cells, CD8+ naive T-cells, and Endothelial cells. Each is linked with SPATA24 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA24-to-partner and partner-to-SPATA24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, naive B-cells grouped by SPATA24-low versus SPATA24-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA24→partner) and Y-score (partner→SPATA24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	naive B-cells →	+0.019	+4.366	.001	.021	3	1
UCEC	CD8+ naive T-cells →	+0.049	+3.364	<.001	.005	3	1
UCEC	Endothelial cells →	-0.041	-3.279	.042	.011	3	1
UCEC	lymphatic Endothelial cells →	-0.026	-3.129	.039	.019	3	1
UCEC	Macrophages M2 →	+0.013	+2.287	.020	.030	3	1
UCEC	MEP →	+0.043	+2.180	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

naive B-cells by SPATA24 expression — COAD

Explore this box plot interactively →