SPATA22

Across TCGA patient cohorts, SPATA22 mutation is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA22-associated genes across cancer lineages are SQSTM1P1, RN7SKP43, and MIR3173. Each is linked with SPATA22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA22-to-partner and partner-to-SPATA22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SQSTM1P1 grouped by SPATA22-low versus SPATA22-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA22→partner) and Y-score (partner→SPATA22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SQSTM1P1 →	+0.137	+6.681	<.001	<.001	3	2
COAD	RN7SKP43 →	+0.276	+6.149	<.001	<.001	3	2
LUAD	MIR3173 →	+0.751	+4.243	.005	.008	3	2
UCEC	CEP72 →	+0.538	+2.700	.001	.005	3	2
READ	GPR6 →	+0.062	+5.039	<.001	.008	3	1
READ	RNU6-1274P →	+0.547	+5.925	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

SQSTM1P1 by SPATA22 expression — READ

Explore this box plot interactively →