SPATA21

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SPATA21 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA21-associated genes across cancer lineages are MIR4510, MIR670, and RN7SL785P. Each is linked with SPATA21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA21-to-partner and partner-to-SPATA21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA21→partner) and Y-score (partner→SPATA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCMIR4510 →+0.400+6.342<.001.00132
LUADMIR670 →+0.171+4.730.005.00532
BRCARN7SL785P →+0.090+3.580.008.00532
LUSCVCY →+0.080+6.102<.001.00132
LUSCPPIAP27 →+0.151+5.081<.001.00432
LUSCRNA5SP411 →+0.860+5.733<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

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