Across TCGA cell cohorts, SPATA21 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA21-associated genes across cancer lineages are CYP11B2, FAM205C, and CLEC4C. Each is linked with SPATA21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA21-to-partner and partner-to-SPATA21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA21→partner) and Y-score (partner→SPATA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CYP11B2 →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	FAM205C →	+0.063	+4.930	<.001	.008	3	1
SKIN	CLEC4C →	+0.054	+4.977	<.001	.007	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
LARGE_INTESTINE	TXNDC15 →	+0.607	+3.364	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Exploration

SPATA21 survival (RNA) · tumor vs normal (RNA) · all SPATA21 data types