SPATA17

Across TCGA cell cohorts, SPATA17 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible SPATA17-associated genes across cancer lineages are IFNA4, TEX43, and CCT8L2. Each is linked with SPATA17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA17-to-partner and partner-to-SPATA17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA4 grouped by SPATA17-low versus SPATA17-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA17→partner) and Y-score (partner→SPATA17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IFNA4 →	+0.115	+4.584	<.001	.001	3	2
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	2
BLOOD_Leukemia	CCT8L2 →	+0.019	+4.874	<.001	.002	3	2
LUNG_SCLC	OR10A6 →	+0.017	+4.643	<.001	.004	3	2
LUNG_NSCLC_LUSC	AVP →	+0.071	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	OXT →	+0.185	+4.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

IFNA4 by SPATA17 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →