SPATA1

Across TCGA patient cohorts, SPATA1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA1-associated genes across cancer lineages are mTOR_pS2448, PI3K-p85, and Shc_pY317. Each is linked with SPATA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA1-to-partner and partner-to-SPATA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SPATA1-low versus SPATA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA1→partner) and Y-score (partner→SPATA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.203	-3.169	.013	.020	3	1
UCEC	PI3K-p85 →	-0.353	-3.169	.002	.020	3	1
UCEC	Shc_pY317 →	-0.192	-3.000	.021	.036	3	1
UCEC	E-Cadherin →	-0.739	-3.169	.005	.020	3	1
UCEC	PCNA →	+0.295	+3.169	.013	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

mTOR_pS2448 by SPATA1 expression — UCEC

Explore this box plot interactively →