SPATA1

Across TCGA pan-cancer cohorts, SPATA1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SPATA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPATA1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA1 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and LIHC are the cancer types where SPATA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.317	<.001	8	view →
KICH	Male	All	−0.535	<.001	7	view →
LIHC	All	All	+0.153	<.001	6	view →
BLCA	Female	All	+0.217	.013	5	view →
LUAD	All	III,IV	−0.322	<.001	4	view →
CHOL	Female	All	+0.686	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SPATA1–LUSC

Open the LUSC breakdown →