SPATA1

Across TCGA cell cohorts, SPATA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,360 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPATA1-associated GO terms across cancer lineages are Sperm motility, Flagellated sperm motility, and Target-directed miRNA degradation. Each is linked with SPATA1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPATA1-to-partner and partner-to-SPATA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sperm motility grouped by SPATA1-low versus SPATA1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA1→partner) and Y-score (partner→SPATA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.090	-0.411	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.090	-0.411	<.001	.001	3	8
LUNG_NSCLC_LUSC	Target-directed miRNA degradation →	+0.092	+0.456	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.116	-0.545	<.001	.001	3	8
SKIN	Negative regulation of myoblast fusion →	+0.076	+0.351	<.001	.002	3	7
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.328	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

Sperm motility by SPATA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →