SPAST

Across TCGA patient cohorts, SPAST mutation is significantly associated with the RNA expression of many other genes, with 4,956 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAST-associated genes across cancer lineages are RN7SL321P, SNORA70D, and LINC02370. Each is linked with SPAST in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAST-to-partner and partner-to-SPAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL321P grouped by SPAST-low versus SPAST-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAST→partner) and Y-score (partner→SPAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RN7SL321P →	+0.098	+4.544	<.001	.009	3	2
LIHC	SNORA70D →	+0.203	+4.758	<.001	.006	3	2
LIHC	LINC02370 →	+0.189	+4.776	<.001	.003	3	2
LIHC	HSPD1P18 →	+0.123	+4.647	<.001	.007	3	2
UCEC	TAF9 →	+0.806	+3.269	<.001	<.001	3	2
LUSC	MIR124-2 →	+0.463	+5.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,956 associations by consensus.

RN7SL321P by SPAST expression — LIHC

Explore this box plot interactively →