SPART

Across TCGA patient cohorts, SPART mutation is significantly associated with the RNA expression of many other genes, with 3,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPART-associated genes across cancer lineages are C1QBP, YWHAE, and NDUFC1. Each is linked with SPART in more than 2 cancer types. Because this analysis shows association rather than direction, both SPART-to-partner and partner-to-SPART results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by SPART-low versus SPART-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPART→partner) and Y-score (partner→SPART) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	C1QBP →	+0.647	+3.346	.001	.004	3	3
UCEC	YWHAE →	+0.289	+1.617	.004	.003	3	3
UCEC	NDUFC1 →	+0.322	+2.136	.002	.002	3	3
STAD	GTF2A2 →	+0.811	+2.526	<.001	.009	3	3
UCEC	COPS3 →	+0.562	+2.115	<.001	<.001	3	3
UCEC	PSMB6 →	+0.469	+2.443	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,937 associations by consensus.

C1QBP by SPART expression — STAD

Explore this box plot interactively →