SPART

Across TCGA patient cohorts, SPART mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPART-associated genes across cancer lineages are FASN, PDCD4, and Caspase-7-cleavedD198. Each is linked with SPART in more than 2 cancer types. Because this analysis shows association rather than direction, both SPART-to-partner and partner-to-SPART results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SPART-low versus SPART-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPART→partner) and Y-score (partner→SPART) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.457	+3.015	.014	.018	3	3
STAD	PDCD4 →	-0.526	-3.459	.008	.005	3	3
STAD	Caspase-7-cleavedD198 →	+0.837	+2.321	.012	.034	3	3
STAD	4E-BP1 →	+0.368	+3.169	.006	.017	3	3
UCEC	PCNA →	+0.194	+2.700	.008	.005	3	3
UCEC	ATM →	-0.372	-1.794	.016	.024	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FASN by SPART expression — STAD

Explore this box plot interactively →