SPART

Across TCGA cell cohorts, SPART mutation is significantly associated with the mutation status of many other genes, with 2,433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPART-associated genes across cancer lineages are MYH9, MON2, and FOXK1. Each is linked with SPART in more than 3 cancer types. Because this analysis shows association rather than direction, both SPART-to-partner and partner-to-SPART results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH9 grouped by SPART-low versus SPART-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPART→partner) and Y-score (partner→SPART) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH9 →	+3.430	+4.545	<.001	<.001	1	4
LARGE_INTESTINE	MON2 →	+2.056	+2.313	.005	.005	1	4
LUNG_NSCLC_LUAD	FOXK1 →	+3.263	+3.851	.005	.005	1	4
BREAST	ACE →	+3.222	+3.222	.009	.009	1	4
BLOOD_Leukemia	KCTD8 →	+3.430	+3.313	.005	.005	1	4
LARGE_INTESTINE	SIN3B →	+2.278	+2.733	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,433 associations by consensus.

MYH9 by SPART expression — BLOOD_Leukemia

Explore this box plot interactively →