SPARC

Across TCGA patient cohorts, SPARC mutation is significantly associated with the RNA expression of many other genes, with 4,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPARC-associated genes across cancer lineages are MTND4LP20, LINC02223, and RPL7AP61. Each is linked with SPARC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4LP20 grouped by SPARC-low versus SPARC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MTND4LP20 →	+0.176	+3.151	<.001	.004	3	2
STAD	LINC02223 →	+0.312	+3.596	<.001	.008	3	2
COAD	RPL7AP61 →	+0.097	+6.142	.001	<.001	3	2
COAD	HSPD1P18 →	+0.360	+4.870	<.001	.002	3	2
UCEC	H3P46 →	+0.053	+2.818	.001	.008	3	2
UCEC	RNA5SP412 →	+0.861	+2.760	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,128 associations by consensus.

MTND4LP20 by SPARC expression — STAD

Explore this box plot interactively →