SPARC

Across TCGA cell cohorts, SPARC mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPARC-associated genes across cancer lineages are EIF3L, HSCB, and CCNB1IP1. Each is linked with SPARC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by SPARC-low versus SPARC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.672	+3.212	<.001	.006	3	1
LARGE_INTESTINE	HSCB →	+0.776	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CCNB1IP1 →	+0.890	+3.212	<.001	.006	3	1
LARGE_INTESTINE	NOP53 →	+0.665	+3.064	<.001	.009	3	1
LARGE_INTESTINE	NUP88 →	+0.661	+3.299	<.001	.004	3	1
LARGE_INTESTINE	STXBP3 →	+0.607	+3.237	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

EIF3L by SPARC expression — LARGE_INTESTINE

Explore this box plot interactively →