Across TCGA patient cohorts, SPANXN5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPANXN5-associated genes across cancer lineages are Annexin-1, Shc_pY317, and 14-3-3_beta. Each is linked with SPANXN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXN5-to-partner and partner-to-SPANXN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN5→partner) and Y-score (partner→SPANXN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.593	+2.827	.019	.035	3	2
UCEC	Shc_pY317 →	-0.175	-3.000	.017	.036	3	2
UCEC	14-3-3_beta →	-0.110	-2.973	.023	.035	3	1
UCEC	JNK2 →	+0.248	+2.817	.009	.036	3	1
UCEC	Notch1 →	+0.186	+3.584	.006	.002	3	1
SKCM	GSK-3_pS9 →	-0.467	-1.773	.011	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

SPANXN5 survival (RNA) · tumor vs normal (RNA) · all SPANXN5 data types