Across TCGA pan-cancer cohorts, SPANXN5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPANXN5’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPANXN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPANXN5 is over-expressed in tumor.

LUSC, HNSC, and KIRP are the cancer types where SPANXN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPANXN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.027	.005	5	view →
HNSC	All	All	+0.052	.036	4	view →
KIRP	All	III,IV	+0.030	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPANXN5 RNA expression & survival · all SPANXN5 data types