SPANXN2

Across TCGA patient cohorts, SPANXN2 mutation is significantly associated with the RNA expression of many other genes, with 3,233 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXN2-associated genes across cancer lineages are MIR6829, PEG10, and RN7SL304P. Each is linked with SPANXN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPANXN2-to-partner and partner-to-SPANXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6829 grouped by SPANXN2-low versus SPANXN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN2→partner) and Y-score (partner→SPANXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR6829 →	+1.466	+3.452	<.001	.008	3	3
UCEC	PEG10 →	+2.045	+2.917	<.001	<.001	3	3
BRCA	RN7SL304P →	+0.144	+5.270	<.001	.001	3	2
UCEC	VTI1A →	+0.421	+3.269	<.001	<.001	3	2
UCEC	AP1S3 →	+0.771	+3.301	<.001	<.001	3	2
UCEC	RMND1 →	+0.813	+2.606	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,233 associations by consensus.

MIR6829 by SPANXN2 expression — COAD

Explore this box plot interactively →