SPANXN2

Across TCGA pan-cancer cohorts, SPANXN2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SPANXN2 data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SPANXN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPANXN2 expression acts as an unfavorable survival marker.

BRCA, UVM, and SKCM are the cancer types where SPANXN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.375	0.839	<.001	84	view →
UVM	OS	Tertile	II,III,IV	0.213	0.718	.002	81	view →
SKCM	OS	Tertile	All	0.147	0.357	<.001	78	view →
UCS	DFS	Tertile	II,III,IV	0.138	0.455	.016	54	view →
KIRC	OS	Tertile	II,III,IV	0.502	0.813	.007	36	view →
SCLC	DFS	Tertile	All	0.247	0.818	.007	36	view →
UCEC	DFS	Tertile	III,IV	0.625	0.811	.029	36	view →
KIRP	OS	Tertile	All	0.216	0.904	<.001	27	view →
SARC	DFS	Tertile	All	0.038	0.591	<.001	18	view →
HNSC	DFS	Tertile	IV	0.222	0.573	.025	9	view →
COAD	OS	Tertile	III,IV	0.168	0.692	.043	9	view →
LIHC	OS	Tertile	All	0.392	0.709	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SPANXN2–BRCA (OS)

Open the BRCA breakdown →