SPANXN2

Across TCGA patient cohorts, SPANXN2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXN2-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and FoxM1. Each is linked with SPANXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXN2-to-partner and partner-to-SPANXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SPANXN2-low versus SPANXN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN2→partner) and Y-score (partner→SPANXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.169	-2.321	.015	.033	3	2
LUSC	Ku80 →	+0.367	+2.349	.017	.019	3	2
UCEC	FoxM1 →	+0.285	+2.321	.007	.006	3	2
UCEC	Notch1 →	+0.182	+3.335	.001	.005	3	2
UCEC	Rab11 →	-0.139	-2.321	.020	.033	3	2
UCEC	Src_pY416 →	-0.221	-2.973	.026	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK_pT183_Y185 by SPANXN2 expression — UCEC

Explore this box plot interactively →