SPANXN2

Across TCGA cell cohorts, SPANXN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 498 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPANXN2-associated GO terms across cancer lineages are Regulation of cell-matrix adhesion, Negative regulation of macrophage inflammatory protein 1 alpha production, and Regulation of actomyosin structure organization. Each is linked with SPANXN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPANXN2-to-partner and partner-to-SPANXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-matrix adhesion grouped by SPANXN2-low versus SPANXN2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN2→partner) and Y-score (partner→SPANXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of cell-matrix adhesion →	-0.054	-0.149	<.001	<.001	3	3
BLOOD_Leukemia	Negative regulation of macrophage inflammatory protein 1 alpha production →	+0.863	+0.006	.006	.009	3	2
SKIN	Regulation of actomyosin structure organization →	-0.031	-0.113	.005	.005	3	2
SKIN	P450-containing electron transport chain →	+0.083	+0.142	<.001	.003	3	2
SKIN	Disaccharide transport →	+0.849	+0.138	<.001	<.001	3	2
SKIN	Sucrose transport →	+0.849	+0.138	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

Regulation of cell-matrix adhesion by SPANXN2 expression — SKIN

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