SPANXA2-OT1

Across TCGA pan-cancer cohorts, SPANXA2-OT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SPANXA2-OT1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPANXA2-OT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPANXA2-OT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and TGCT show a favorable association.

UCEC, READ, and HNSC are the cancer types where SPANXA2-OT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.548	0.702	<.001	86	view →
READ	OS	Tertile	III,IV	0.219	0.821	<.001	66	view →
HNSC	OS	Tertile	II,III,IV	0.563	0.680	.009	61	view →
UVM	OS	Tertile	All	0.356	0.945	.001	56	view →
PAAD	OS	Quartile	All	0.656	0.327	.002	25	view →
LIHC	OS	Quartile	III,IV	0.324	0.667	<.001	19	view →
TGCT	DFS	Quartile	All	0.882	0.594	.004	16	view →
STAD	OS	Median	II,III,IV	0.453	0.253	.013	14	view →
MESO	OS	Tertile	IV	0.256	0.791	.008	12	view →
UCS	OS	Tertile	IV	0.773	0.360	.024	12	view →
LGG	OS	Tertile	All	0.433	0.695	.007	11	view →
BRCA	DFS	Median	III,IV	0.557	0.387	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SPANXA2-OT1–UCEC (DFS)

Open the UCEC breakdown →