SPANXA2-OT1

Across TCGA pan-cancer cohorts, SPANXA2-OT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SPANXA2-OT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPANXA2-OT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPANXA2-OT1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

THCA, KIRC, and BRCA are the cancer types where SPANXA2-OT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPANXA2-OT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.193	<.001	8	view →
KIRC	All	All	−0.044	<.001	8	view →
BRCA	All	All	+0.068	.013	4	view →
LUAD	Female	All	+0.187	<.001	3	view →
BLCA	All	IV	−0.141	.032	3	view →
UCEC	All	IV	−0.114	.001	2	view →
KICH	Female	II,III,IV	−0.095	.006	2	view →
PRAD	All	All	−0.045	.006	2	view →
CHOL	All	All	+0.100	.049	1	view →
HNSC	Male	All	−0.034	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SPANXA2-OT1–THCA

Open the THCA breakdown →