SPAG9

Across TCGA patient cohorts, SPAG9 mutation is significantly associated with the RNA expression of many other genes, with 2,838 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG9-associated genes across cancer lineages are ANKRD63, BUB1B, and CCDC117. Each is linked with SPAG9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG9-to-partner and partner-to-SPAG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD63 grouped by SPAG9-low versus SPAG9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG9→partner) and Y-score (partner→SPAG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ANKRD63 →	+0.240	+2.757	.002	.003	3	3
UCEC	BUB1B →	+0.568	+1.773	.004	.008	3	3
UCEC	CCDC117 →	+0.380	+2.111	.003	.003	3	3
UCEC	CHCHD4 →	+0.355	+2.140	<.001	.002	3	3
UCEC	CCDC51 →	+0.360	+2.243	.007	.005	3	3
UCEC	C9orf64 →	+0.575	+1.935	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,838 associations by consensus.

ANKRD63 by SPAG9 expression — COAD

Explore this box plot interactively →