SPAG9

Across TCGA pan-cancer cohorts, SPAG9 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SPAG9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPAG9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPAG9 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where SPAG9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.161	<.001	12	view →
KIRC	All	All	+0.416	<.001	10	view →
THCA	Male	II,III,IV	−0.856	<.001	8	view →
KIRP	All	II,III,IV	+0.620	.003	8	view →
KICH	Female	All	−1.074	<.001	7	view →
CHOL	All	All	+0.861	.003	4	view →
COAD	Female	All	−0.481	.007	3	view →
LUAD	All	All	−0.241	.032	3	view →
UCEC	All	All	−1.052	<.001	2	view →
LUSC	Female	All	−0.524	.015	2	view →
LIHC	All	All	+0.334	.009	2	view →
BRCA	Female	All	−0.188	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SPAG9–HNSC

Open the HNSC breakdown →