SPAG9

Across TCGA patient cohorts, SPAG9 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG9-associated genes across cancer lineages are Beclin, Caspase-7-cleavedD198, and FoxM1. Each is linked with SPAG9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG9-to-partner and partner-to-SPAG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Beclin grouped by SPAG9-low versus SPAG9-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG9→partner) and Y-score (partner→SPAG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Beclin →	+0.301	+3.000	.007	.036	3	2
STAD	Caspase-7-cleavedD198 →	+0.971	+3.000	.011	.036	2	3
UCEC	FoxM1 →	+0.196	+1.736	.028	.007	3	2
UCEC	Ku80 →	+0.242	+1.750	.003	.004	3	2
UCEC	mTOR_pS2448 →	-0.159	-3.893	.002	<.001	3	2
UCEC	PCNA →	+0.259	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Beclin by SPAG9 expression — STAD

Explore this box plot interactively →