SPAG9

Across TCGA cell cohorts, SPAG9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,261 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPAG9-associated GO terms across cancer lineages are Regulation of translational initiation, Regulation of protein-containing complex disassembly, and Endosomal transport. Each is linked with SPAG9 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPAG9-to-partner and partner-to-SPAG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by SPAG9-low versus SPAG9-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG9→partner) and Y-score (partner→SPAG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translational initiation →	+0.070	+0.702	<.001	.005	3	15
STOMACH	Regulation of protein-containing complex disassembly →	+0.075	+1.565	<.001	<.001	3	15
LARGE_INTESTINE	Endosomal transport →	+0.060	+1.231	<.001	<.001	3	15
STOMACH	Cytosolic transport →	+0.088	+1.582	<.001	<.001	3	15
BREAST	Microtubule nucleation →	+0.104	+1.144	<.001	.001	3	14
LIVER	Regulation of cytokinesis →	+0.082	+1.046	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,261 associations by consensus.

Regulation of translational initiation by SPAG9 expression — LUNG_NSCLC_LUSC

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