SPAG9

Across TCGA cell cohorts, SPAG9 mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAG9-associated genes across cancer lineages are DMRTC2, OR4F4, and SYCP1. Each is linked with SPAG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG9-to-partner and partner-to-SPAG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTC2 grouped by SPAG9-low versus SPAG9-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG9→partner) and Y-score (partner→SPAG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DMRTC2 →	+0.158	+4.523	<.001	.003	3	1
LUNG_SCLC	OR4F4 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	SYCP1 →	+0.145	+4.044	<.001	.009	3	1
BLOOD_Lymphoma	RAX →	+0.428	+3.925	.001	.006	3	1
BLOOD_Lymphoma	ASZ1 →	+1.249	+3.906	<.001	.001	3	1
BLOOD_Lymphoma	SLC6A1 →	+0.152	+3.421	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

DMRTC2 by SPAG9 expression — LUNG_SCLC

Explore this box plot interactively →