SPAG6

Across TCGA patient cohorts, SPAG6 protein abundance is significantly associated with the RNA expression of many other genes, with 4,534 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPAG6-associated genes across cancer lineages are GINS1, SPEF1, and E2F1. Each is linked with SPAG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG6-to-partner and partner-to-SPAG6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAG6 versus GINS1 in LUAD, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG6→partner) and Y-score (partner→SPAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS1 →	-0.647	-0.386	<.001	<.001	3	2
LUAD	SPEF1 →	+0.711	+0.602	.004	<.001	3	2
LUAD	E2F1 →	-1.004	-0.526	<.001	<.001	3	2
LUAD	SUV39H1 →	-0.408	-0.412	<.001	.001	3	2
LSCC	OIP5 →	-0.558	-0.452	<.001	.002	3	2
LUAD	RP1 →	+1.087	+0.559	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,534 associations by consensus.

SPAG6 vs GINS1 — LUAD

Explore this scatter interactively →