SPAG6

Across TCGA pan-cancer cohorts, SPAG6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPAG6 data layer compared with 2 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher SPAG6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPAG6 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

DLBC, LIHC, and UCEC are the cancer types where SPAG6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.362	0.955	<.001	88	view →
LIHC	OS	Quartile	All	0.669	0.844	<.001	44	view →
UCEC	DFS	Quartile	All	0.438	0.756	<.001	40	view →
BRCA	DFS	Quartile	II,III,IV	0.959	0.901	.003	39	view →
ACC	DFS	Median	IV	0.142	0.547	<.001	31	view →
SKCM	OS	Tertile	All	0.459	0.295	.002	29	view →
LAML	DFS	Quartile	All	0.320	0.649	.012	26	view →
BLCA	OS	Tertile	III,IV	0.510	0.291	.008	18	view →
STAD	OS	Median	IV	0.642	0.194	.003	13	view →
MESO	OS	Quartile	III,IV	0.717	0.423	.006	12	view →
CESC	OS	Median	II,III,IV	0.835	0.664	.020	8	view →
PAAD	DFS	Quartile	All	0.493	0.198	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPAG6–DLBC (DFS)

Open the DLBC breakdown →