SPAG6

Across TCGA patient cohorts, SPAG6 mutation is significantly associated with the RNA expression of many other genes, with 1,331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG6-associated genes across cancer lineages are SEPTIN14P2, CENPH, and NCAPH2. Each is linked with SPAG6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG6-to-partner and partner-to-SPAG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P2 grouped by SPAG6-low versus SPAG6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG6→partner) and Y-score (partner→SPAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPTIN14P2 →	+0.202	+2.395	.003	.004	3	3
UCEC	CENPH →	+0.579	+2.329	<.001	.003	3	3
UCEC	NCAPH2 →	+0.711	+2.938	<.001	<.001	3	3
UCEC	TIMM44 →	+0.349	+2.850	.001	.001	3	3
UCEC	EXOSC9 →	+0.422	+2.439	.002	.001	3	3
COAD	NDUFA6 →	+0.602	+3.348	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

SEPTIN14P2 by SPAG6 expression — LUAD

Explore this box plot interactively →