SPAG6

Across TCGA patient cohorts, SPAG6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG6-associated genes across cancer lineages are PCNA, PDCD4, and ATM. Each is linked with SPAG6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG6-to-partner and partner-to-SPAG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SPAG6-low versus SPAG6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG6→partner) and Y-score (partner→SPAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.301	+2.815	.027	.036	2	3
UCEC	PDCD4 →	-0.473	-1.678	.008	.023	3	2
UCEC	ATM →	-0.589	-2.087	<.001	.005	3	2
UCEC	Bak →	+0.189	+1.678	.048	.023	3	2
UCEC	Cyclin-B1 →	+0.583	+2.700	.006	.006	3	2
COAD	4E-BP1_pT70 →	+0.137	+2.815	.036	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by SPAG6 expression — COAD

Explore this box plot interactively →