SPAG6

Across TCGA cell cohorts, SPAG6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPAG6-associated genes across cancer lineages are GZMK, TMEM196, and CDR1. Each is linked with SPAG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG6-to-partner and partner-to-SPAG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by SPAG6-low versus SPAG6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG6→partner) and Y-score (partner→SPAG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GZMK →	+0.522	+4.037	<.001	.004	3	1
BLOOD_Leukemia	TMEM196 →	+0.036	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CDR1 →	+0.065	+4.060	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	F11 →	+0.096	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GZMK by SPAG6 expression — BLOOD_Leukemia

Explore this box plot interactively →