SPAG5

Across TCGA pan-cancer cohorts, SPAG5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPAG5 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPAG5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPAG5 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where SPAG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.384	1.000	.003	11	view →
HNSC	OS	Median	All	0.602	0.782	.030	2	view →
LSCC	OS	Tertile	All	0.927	0.743	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPAG5–LUAD (DFS)

Open the LUAD breakdown →